Publications - Papers


Foster, N.L., Heidebrink, J.L., Clark, C.M., Jagust, W.J., Arnold, S.E., Barbas, N.R., DeCarli, C., Turner, R.S., Koeppe, R.A., Higdon, R., Minoshima, S.
Accuracy of FDG-PET in Distinguishing frontotemporal dementia and Alzheimer's disease.
In press: Neurology.

M. Yoshita, E. Fletcher, D. Harvey, M. Ortega, O. Martinez, D.M. Mungas, B.R. Reed, C. DeCarli.
Extent and distribution of white matter hyperintensities in normal aging, MCI and AD
Neurology 67 December (2 of 2) 2006, pp. 2192-2198. pdf

Rhoda Au, Joseph M. Massaro, Philip A. Wolf, Megan E. Young, Alexa Beiser, Sudha Seshadri, Ralph B. D'Agostino, Charles DeCarli (2006).
Association of white matter hyperintensity volume with decreased cognitive functioning: the Framingham Heart Study.
Archives of Neurology 63(2):246-50. pdf

Wu Nordahl C, Ranganath C, Yonelinas AP, DeCarli C, Fletcher E, Jagust WJ.
White matter changes compromise prefrontal cortex function in healthy elderly individuals.
Journal Cognitive Neuroscience 18:3, pp. 418-429. pdf


Yoshita M, Fletcher E, DeCarli C.
Current Concepts of Analysis of Cerebral White Matter Hyperintensities on Magnetic Resonance Imaging.
Top Magn Reson Imaging Volume 16, Number 6, December 2005, pp. 399-406. pdf

Jagust W, Harvey D, Mungas D, Haan M (2005).
Central obesity and the aging brain.
Archives of Neurology 62(10):1545-8. pdf

DeCarli C, Massaro J, Harvey D, Hald, J, Tullberg M, Au R, Beiser A, D'Agostino R, Wolf PA (2005).
Measures of brain morphology and infarction in the framingham heart study: establishing what is normal.
Neurobiology of Aging 26(4): 491:510. pdf

DeCarli C, Fletcher E, Ramey V, Harvey D, Jagust WJ (2005).
Anatomical mapping of white matter hyperintensities (WMH): exploring the relationships between periventricular WMH, deep WMH, and total WMH burden.
Stroke 36: 50-55. pdf

Fleisher, A., M. Grundman, C.R. Jack, Jr., R.C. Petersen, C. Taylor, H.T. Kim, D.H. Schiller, V. Bagwell, D. Sencakova, M.F. Weiner, C. DeCarli, S.T. DeKosky, C.H. van Dyck, and L.J. Thal (2005).
Sex, apolipoprotein E epsilon4 status, and hippocampal volume in mild cognitive impairment.
Archives of Neurology 62(6): 953-7. pdf

Mungas, D., Harvey, D., Reed, B. R., Jagust, W. J., DeCarli, C., Beckett, L., Mack, W. J., Kramer, J. H., Weiner, M. W., Schuff, N., & Chui, H. C. (2005).
Longitudinal volumetric MRI change and rate of cognitive decline.
Neurology 65(4), 565-71.

Wu Nordahl C, Ranganath C, Yonelinas AP, DeCarli C, Reed BR, Jagust WJ (2005).
Different mechanisms of episodic memory failure in mild cognitive impairment.
Neuropsychologia 43(11) 1688-1697. pdf

Wright CB, Paik MC, Stabler SP, Allen RH, Sacco RL, DeCarli C (2005).
Total homocysteine is associated with white matter hyperintensity volume: the Northern Manhattan Study.
Stroke 36(6):1207-11. pdf

Zarow C, Vinters HV, Ellis WG, Weiner MW, Mungas D, White L, Chui HC (2005).
Correlates of hippocampal neuron number in Alzheimer's disease and ischemic vascular dementia.
Annals of Neurology 57(6):896-903. pdf


Atwood, L. D., Wolf, P. A., Heard-Costa, N. L., Massaro, J. M., Beiser, A., D'Agostino, R. B. & DeCarli, C. (2004).
Genetic variation in white matter hyperintensity volume in the Framingham Study.
Stroke 35(7):1609-13. pdf

DeCarli, C., Mungas, D., Harvey, D., Reed, B., Weiner, M., Chui, H., & Jagust, W. (2004).
Memory impairment, but not cerebrovascular disease, predicts progression of MCI to dementia.
Neurology 63 (2): 220-227.

Eberling, J.L., C. Wu, Tong-Turnbeaugh, R., & Jagust, W.J. (2004).
Estrogen- and tamoxifen-associated effects on brain structure and function.
Neuroimage 21(1): 364-71. pdf

Higdon, R., Foster, N.L., Koeppe, R.A., DeCarli, C.S., Jagust, W.J., Clark, C.M., Barbas, N.R., Arnold, S.E., Turner, R.S., Heidebrink, J.L., & Minoshima, S. (2004).
A comparison of classification methods for differentiating fronto-temporal dementia from Alzheimer's disease using FDG-PET imaging.
Stat Med 23(2): 315-26. pdf

Jeerakathil, T., Wolf, P. A., Beiser, A., Hald, J. K., Au, R., Kase, C. S., Massaro, J. M. & DeCarli, C. (2004).
Cerebral microbleeds: prevalence and associations with cardiovascular risk factors in the Framingham Study.
Stroke 35(8):1831-5. pdf

Jeerakathil, T., Wolf, P. A., Beiser, A., Massaro, J., Seshadri, S., D'Agostino, R. B. & DeCarli, C. (2004).
Stroke risk profile predicts white matter hyperintensity volume: the Framingham Study.
Stroke 35(1): 857-61. pdf

Massaro, J.M., D'Agostino, R.B. Sr., Sullivan, L.M., Beiser, A., DeCarli, C., Au, R., Elias, M.F., & Wolf, P.A. (2004).
Managing and analysing data from a large-scale study on Framingham offspring relating brain structure to cognitive function.
Stat Med 23(2): 351-67. pdf

Petkov, C.I., Wu, C.C., Eberling, J.L., Mungas, D., Zrelak, P.A.,Yonelinas, A.P., Haan, M.N., & Jagust, W.J. (2004).
Correlates of memory function in community dwelling elderly: The importance of white matter hyperintensities.
Journal of the International Neuropsychological Society 10(3) 371-381. pdf

Reed, B.R., Eberling, J.L., Mungas, D., Weiner, M., Kramer, J.H., Jagust, W.J. (2004).
Effects of white matter lesions and lacunes on cortical function.
Archives of Neurology 61(10), 1545-50. pdf

Seshadri S, Wolf PA, Beiser A, Elias MF, White R, Au R, Tocco M, Kase CS, D'Agostino RB, DeCarli C (2004).
Stroke risk profile, brain volume, and cognitive function: the Framingham Offspring Study.
Neurology 63(9):1591-1599.

Tomaszewski Farias, S., & Jagust, W. (2004).
Neuroimaging in non-Alzheimer's dementias.
Clinical Neuroscience Research 3(6), 383-395.

Tomaszewski Farias, S., Mungas, D., Reed, B., Haan, M., & Jagust, W. (2004).
Everyday functioning in relation to cognitive functioning and neuroimaging in community dwelling Hispanic and Non-Hispanic older adults.
Journal of the International Neuropsychological Society 10 (3), 342-54. pdf

Tullberg, M., Fletcher, E., DeCarli, C., Mungas, D.M., Reed, B.R., Harvey, D.J., Weiner, M., Chui, H., & Jagust, W.M. (2004).
White matter lesions impair frontal lobe function regardless of their location.
Neurology 63:2 246-53.


Grundman M, Jack CR Jr, Petersen RC, Kim HT, Taylor C, Datvian M, Weiner MF, DeCarli C, DeKosky ST, van Dyck C, Darvesh S, Yaffe K, Kaye J, Ferris SH, Thomas RG, Thal LJ (2003).
Hippocampal volume is associated with memory but not nonmemory cognitive performance in patients with mild cognitive impairment.
Journal of Molecular Neuroscience 20(3):241-8.

Theodore, W.H., DeCarli, C., & Gaillard, W.D. (2003).
Total cerebral volume is reduced in patients with localization-related epilepsy and a history of complex febrile seizures.
Arch Neurol 60(2): 250-2. pdf

Eberling, J.L., Wu, C.C., Haan, M.N., Mungas, D.M., Buonocore, M.H., & Jagust, W.J. (2003).
Preliminary evidence that estrogen protects against age-related hippocampal atrophy.
Neurobiology of Aging 24(5):725-32. pdf


Carmelli D, Reed T, DeCarli C. (2002).
A bivariate genetic analysis of cerebral white matter hyperintensities and cognitive performance in elderly male twins.
Neurobiology of Aging 23: 413-420. pdf

Carmelli, D., DeCarli, C., Swan, G.E., & Reed, T. (2002).
Quantitative genetic modeling of regional brain volumes and cognitive performance in older male twins.
Biological Psychology 61: 139-155. pdf

Eberling, J.L. (2002).
Oestrogen has neuroprotective effects and may reduce the risk of Alzheimer's disease.
Expert Opin Biol Ther 2: 647-657.

Frisoni GB, Geroldi C, Beltramello A, Bianchetti A, Binetti G, Bordiga G, DeCarli C, Laakso MP, Akkawi NM, Pihlajamaki M, Soininen H, Testa C, Zanetti O, Trabuchhi M (2002).
Radial width of the temporal horn: A measure sensitive to Alzheimer's disease.
American Journal of Neuroradiology 23: 35-47. pdf

Geschwind DH, Miller B, DeCarli C, Carmelli C (2002).
Heritability of lobar brain volumes in twins supports genetic models of cerebral laterality.
PNAS 99: 3176-3181. pdf

Jagust, W. J., Eberling, J. L., Wu, C. C., Finkbeiner, A., Mungas, D., Valk, P. E., & Haan, M. N. (2002).
Brain function and cognition in a community sample of elderly Latinos.
Neurology 59(3): 378-83.

Mungas, D., Reed, B.R., Jagust, W.J., DeCarli, C., Mack, W.J., Kramer, J.H., Weiner, M.W., Schuff, N., & Chui, H.C. (2002).
Volumetric MRI predicts rate of cognitive decline related to AD and cerebrovascular disease.
Neurology 59:867-873.

Wu, C. C., Mungas, D., Eberling, J. L., Reed, B. R., & Jagust, W. J. (2002).
Imaging interactions between Alzheimer's disease and cerebrovascular disease.
Ann N Y Acad Sci, 977: 403-10. pdf

Wu, C. C., Mungas, D., Petkov, C. I., Eberling, J. L., Zrelak, P. A., Buonocore, M. H., Brunberg, J. A., Haan, M. N., & Jagust, W. J. (2002).
Brain structure and cognition in a community sample of elderly Latinos.
Neurology 59(3): 383-91.


Mungas D, Jagust WJ, Reed BR, Kramer JH, Weiner MW, Schuff N, Norman D, Mack WJ, Chui HC. (2001).
MRI predictors of cognition in subcortical ischemic vascular disease and Alzheimer's disease.
Neurology 57:2229-2235.

Reed, B.R., Eberling, J.L., Mungas, D., Weiner, M., Jagust, W.J. (2001).
Frontal lobe hypometabolism predicts cognitive decline in patients with lacunar infarcts.
Arch Neurol 58:493-497. pdf


Reed, BR; Eberling, JL; Mungas, D; Weiner, MW; Jagust, WJ (2000).
Memory failure has different mechanisms in subcortical stroke and Alzheimer's disease.
Annals of Neurology 48(3):275-84.

Bankiewicz, KS; Eberling, JL; Kohutnicka, M; Jagust, W; Pivirotto, P; Bringas, J; Cunningham, J; Budinger, TF; Harvey-White, J. (2000).
Convection-enhanced delivery of AAV vector in parkinsonian monkeys; in vivo detection of gene expression and restoration of dopaminergic function using pro-drug approach.
Experimental Neurology 164(1):2-14. pdf

Mungas, D; Reed, BR (2000).
Application of item response theory for development of a global functioning measure of dementia with linear measurement properties.
Statistics in Medicine 19(11-12):1631-44. pdf

Mungas, D; Reed, BR; Marshall, SC; González, HM (2000).
Development of psychometrically matched English and Spanish language neuropsychological tests for older persons.
Neuropsychology 14(2):209-23.

Capizzano, AA; Schuff, N; Amend, DL; Tanabe, JL; Norman, D; Maudsley, AA; Jagust, W; Chui, HC; Fein, G; Segal, MR; Weiner, MW (2000).
Subcortical ischemic vascular dementia: assessment with quantitative MR imaging and 1H MR spectroscopy.
American Journal of Neuroradiology 21(4):621-30. pdf

Jagust, WJ; Noseworthy, JH (2000).
Brain atrophy as a surrogate marker in MS: faster, simpler, better?
Neurology 54(4):782-3.

O'Neill, J; Eberling, JL; Schuff, N; Jagust, W; Reed, B; Soto, G; Ezekiel, F; Klein, G; Weiner, MW (2000).
Method to correlate 1H MRSI and 18FDG-PET.
Magnetic Resonance in Medicine 43(2):244-50. pdf

Chui, HC; Mack, W; Jackson, JE; Mungas, D; Reed, BR; Tinklenberg, J; Chang, FL; Skinner, K; Tasaki, C; Jagust, WJ (2000).
Clinical criteria for the diagnosis of vascular dementia: a multicenter study of comparability and interrater reliability.
Archives of Neurology 57(2):191-6. pdf

Hargrave, R; Geck, LC; Reed, B; Mungas, D (2000).
Affective behavioural disturbances in Alzheimer's disease and ischaemic vascular disease.
Journal of Neurology, Neurosurgery and Psychiatry 68(1):41-6. pdf


Haan, MN; Shemanski, L; Jagust, WJ; Manolio, TA; Kuller, L (1999).
The role of APOE epsilon4 in modulating effects of other risk factors for cognitive decline in elderly persons.
Journal of the American Medical Association 282(1):40-6. pdf

Kwan, LT; Reed, BR; Eberling, JL; Schuff, N; Tanabe, J; Norman, D; Weiner, MW; Jagust, WJ (1999).
Effects of subcortical cerebral infarction on cortical glucose metabolism and cognitive function.
Archives of Neurology 56(7):809-14. pdf

Tanabe, JL; Ezekiel, F; Jagust, WJ; Reed, BR; Norman, D; Schuff, N; Weiner, MW; Chui, H; Fein, G (1999).
Magnetization transfer ratio of white matter hyperintensities in subcortical ischemic vascular dementia.
American Journal of Neuroradiology 20(5):839-44. pdf

Eberling, JL; Bankiewicz, KS; Pivirotto, P; Bringas, J; Chen, K; Nowotnik, DP; Steiner, JP; Budinger, TF; Jagust, WJ (1999).
Dopamine transporter loss and clinical changes in MPTP-lesioned primates.
Brain Research 832(1-2):184-7. pdf


Jagust, WJ; Haan, MN; Reed, BR; Eberling, JL (1998).
Brain perfusion imaging predicts survival in Alzheimer's disease.
Neurology 51(4):1009-13.

Reed, BR; Paller, KA; Mungas, D (1998).
Impaired acquisition and rapid forgetting of patterned visual stimuli in Alzheimer's disease.
Journal of Clinical and Experimental Neuropsychology 20(5):738-49.

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