By leveraging the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) cohort, we plan to examine the impact of disparities in vascular risk factors on brain health utilizing cutting edge MRI techniques within a large, understudied population of diverse Latinos spanning the age range of risk for stroke and dementia. We will also characterize the biological substrates of stroke, MCI and AD among the various racial admixtures in this deeply phenotyped cohort.