Publications

Below are selected highlights from IDeA Lab researchers. Sort by Categories, on the right of the page, to organize into topic subgroups. For comprehensive publications, view the People page for each researcher's Google Scholar.

A data-driven, multi-domain brain gray matter signature as a powerful biomarker associated with several clinical outcomes

by Evan Fletcher
November 23, 2024

We describe the properties of a brain gray matter region ("Union Signature") that is derived from four behavior-specific, data-driven signatures in a discovery cohort.

Neurocognitive profiles are associated with subsequent brain integrity in a sample of Hispanics/Latinos: Findings from the SOL-INCA-MRI study (HCHS/SOL)

by Shraddha Sapkota
July 17, 2024

We examined cognitive constructs and associations with subsequent hippocampal volume (HV) and white matter hyperintensity volume (WMHV).

Trends in Intracranial and Cerebral Volumes of Framingham Heart Study Participants Born 1930 to 1970

by Charles Decarli
May 01, 2024

Computation & Neuroimaging

Objective: To examine environmental influences by testing whether time-dependent secular differences occurred in cranial and brain volumes and cortical thickness over birth decades spanning 1930 to 1970.

Amyloid pathology and vascular risk are associated with distinct patterns of cerebral white matter hyperintensities: A multicenter study in 3132 memory clinic patients

by Charles Decarli
March 13, 2024

We aimed to identify WMH locations associated with vascular risk or cerebral amyloid-β1-42 (Aβ42)-positive status.

White matter hyperintensities in diverse populations: A systematic review of literature in the United States

by Vista Farkhondeh
January 11, 2024

Diversity & Health Disparities

As the United States’ (US) elderly population becomes increasingly diverse, it is imperative that research studies address cognitive health in diverse populations of older Americans.

A novel neuroimaging signature for ADRD risk stratification in the community

by Charles Decarli
November 21, 2023

We identified and validated a magnetic resonance imaging (MRI) signature for Alzheimer’s disease (AD) and related dementias (ARDR).

MISPEL: A supervised deep learning harmonization method for multi-scanner neuroimaging data

by Pauline Maillard
August 03, 2023

Computation & Neuroimaging

In this study, we propose MISPEL (Multi-scanner Image harmonization via Structure Preserving Embedding Learning), a supervised multi-scanner harmonization method that is naturally extendable to more than two scanners.

Toward a statistical validation of brain signatures as robust measures of behavioral substrates

by Evan Fletcher
June 01, 2023

In this validation study, we produced signature models that replicated model fits to outcome and outperformed other commonly used measures.

Neuroimaging standards for research into small vessel disease-advances since 2013

by Charles Decarli
May 23, 2023

Using a similar approach to that adopted in STRIVE-1, we updated the guidance on neuroimaging of vascular changes in studies of ageing and neurodegeneration to create STRIVE-2.

Vascular risk predicts plasma amyloid β 42/40 through cerebral amyloid burden in Apolipoprotein E ε4 carriers

by Shraddha Sapkota
April 06, 2023

We examined whether key vascular and genetic risk impact the association between cerebral amyloid burden and plasma aβ (amyloid β) 42/40 in nondemented older adults.

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