The proposed intergenerational research study would increase our understanding of cognitive resilience in late-life older adults, and examines the relation of midlife biomarkers of brain and cardiovascular health in offspring and cognitive resilience in parent. Preserving cognitive resilience through early, mid, and late life biomarkers is a topic of high public health significance, since designing of preventive strategies through life course can offer stronger potential for slowing or reducing the risk of developing cognitive loss in late-life.